By Manish Choudhary
A fire in the cabin during a test before launch killed three astronauts.
The Space Shuttle Challenger exploded soon after liftoff, killing all seven crew members.
The Space Shuttle Columbia broke apart during re-entry, resulting in the deaths of all seven astronauts.
Three cosmonauts died when their spacecraft lost pressure during re-entry.
Soviet cosmonaut Vladimir Komarov died in a crash landing when his spacecraft's parachutes failed.
Virgin Galactic's SpaceShipTwo broke apart during a test flight, killing one pilot.
Air Force pilot Michael J. Adams died when his aircraft broke apart during re-entry from space.